Nobiletin enhances Pirarubicin chemosensitivity of breast cancer cell MDA-MB-231 by regulating PER2
نویسندگان
چکیده
To explore the potential mechanism of nobiletin in improving sensitivity breast cancer MDA-MB-231 cells to Pirarubicin. were randomly divided into Control group, Nobiletin Pirarubicin group and co-Pirarubicin group. CCK-8 assay was used detect inhibitory effect on proliferation cells, cell cycle apoptosis detected by flow cytometry. The combined with migration repair ability scratch test. Western blotting determine Period2 (PER2), apoptosis-related proteins Bax BCL-2 expression levels cells. results showed that enhanced nobiletin. Compared or alone, promoted protein Bax, reduced apoptosis-inhibiting BCL-2. combination significantly inhibited which may be mediated enhancement PER2
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ژورنال
عنوان ژورنال: E3S web of conferences
سال: 2021
ISSN: ['2555-0403', '2267-1242']
DOI: https://doi.org/10.1051/e3sconf/202123302010